Ever wondered about the neurobiology of memory — how the brain stores information? And, if you know slightly more, how information is stored beyond the hippocampus, or what happens to memory during recall? If you have anything to do with memory — even having a slight interest in the topic — the journal Neurobiology of Learning and Memory now hosts a special issue on the role of protein synthesis in memory. The issue is packed with updates on the findings and controversies on this topic, and it is certain to bring you to up to date on the neurobiology of memory.
As the editor of this issue, Paul E. Gold, notes in his introduction:
The goal of collecting these papers was not to find a single clear view, laying to rest one alternative view or another—a rather delusional goal at best. Instead, the attempt was to provide a venue through which different perspectives could appear together, with the understanding that all contributors are interested in a common purpose, to identify the ways in which brains make and hold new memories.
So, this issue will probably prove important with regard to mapping out the agreements and disagreements. As Gold notes:
Across these papers, there is agreement on the basic findings. All authors agree that proteins and protein synthesis are important to memory formation, but disagree on the question of whether new protein synthesis specifically triggered by an event is important for the formation of memory for that event. Some of the alternatives suggested include protein synthesis needed to maintain cell integrity, to replenish proteins ‘consumed’ by plasticity mechanisms, and to provide particular proteins that might be modified by experience, with long-lasting modification perhaps themselves representing cellular memory.
The diversity of opinion collected in this special issue, and briefly summarized here, offers an opportunity for readers to examine how different researchers, each sharing a common goal of understanding how memories are made, can view the same data set and come away with disparate opinions. In this way, the readers may find this discourse useful in identifying the important questions, if not the answers, surrounding the roles of protein synthesis in memory.